Beyond the fact that you now find yourself in possession of a handful of powerful, might as well be 'magical' creatures, you can't die no matter how badly you injured you become? A handful of these Pokemon are telepaths, able to speak directly to your mind as well as read it if they wish. Most Pokemon that should be able to be ridden while flying can't until you teach them Fly. Team Rocket were able to create a mutagen that spread through the air, infecting people with the power of Pokemon and appropriate physical changes. The world was almost brought to an end by giant rock and ice creatures. The list goes on, really.